Open Access to Latin American Natural Products: Databases for Researchers

SistematX, The Federal University of Paraiba Brazil

The database comprised 9,514 plants' secondary metabolites and was developed at the Federal University of Paraiba. It allows the generation and visualization of 1H and 13C nuclear magnetic resonance spectra, the calculation of physicochemical (drug-like and lead-like) properties, and biological activity profiles. It presents the exact location of the species from which the compounds were isolated.

Link to database http://sistematx.ufpb.br.

Costa, R.P., Lucena, L.F., Silva, L.M.A., Zocolo, G.J., Herrera-Acevedo, C., Scotti, L., Da-Costa, F.B., Ionov, N., Poroikov, V., Muratov, E.N. and Scotti, M.T., 2021. The SistematX web portal of natural products: An update. Journal of Chemical Information and Modeling, 61(6), pp.2516-2522.

NuBBEDB The São Paulo State University and the University of São Paulo, Brazil

The Nuclei of Bioassays, Ecophysiology and Biosynthesis of Natural Products Database (NuBBEDB) includes 2,223 molecules from plants, microorganisms, and terrestrial and marine animals derived from natural products of Brazilian biodiversity. It was Developed by the São Paulo State University and the University of São Paulo. It provides validated information, chemical descriptors, species sources, geographic locations, spectroscopic data (NMR), and pharmacological properties.

Link to database: http://nubbe.iq.unesp.br/portal/nubbe-search.html.

Pilon, A.C., Valli, M., Dametto, A.C., Pinto, M.E.F., Freire, R.T., Castro-Gamboa, I., Andricopulo, A.D. and Bolzani, V.S., 2017. NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity. Scientific Reports, 7(1), p.7215.

BIOFACQUIM The National Autonomous University of Mexico, Mexico

Compound database of natural products isolated and characterized in Mexico at the National Autonomous University of Mexico School of Chemistry and other Mexican institutions. It contains 553 compounds from plants, fungi, propolis, and marine animals, and information about chemical descriptors, species sources, geographic locations, and pharmacological properties are provided.

Link to database: https://figshare.com/articles/dataset/BIOFACQUIM_V2_sdf/11312702.

Pilón-Jiménez, B.A., Saldívar-González, F.I., Díaz-Eufracio, B.I. and Medina-Franco, J.L., 2019. BIOFACQUIM: a Mexican compound database of natural products. Biomolecules, 9(1), p.31.

PeruNPDB The Catholic University of Santa Maria, Peru

The Peruvian Natural Products Database (PeruNPDB) contains 280 natural products isolated from animals and plants. Created and curated at the Catholic University of Santa Maria, it is intended to be used in a variety of tasks, such as virtual screening campaigns against various disease targets or biological endpoints. Information provided includes identification code (ID), the chemical name, bibliographic reference, kingdom, genus, and species of the natural product, SMILES notation, and classification of the natural product.

Link to database: https://perunpdb.com.pe/

Barazorda-Ccahuana, H.L., Ranilla, L.G., Candia-Puma, M.A., Cárcamo-Rodriguez, E.G., Centeno-Lopez, A.E., Davila-Del-Carpio, G., Medina-Franco, J.L. and Chávez-Fumagalli, M.A., 2023. PeruNPDB: the Peruvian Natural Products Database for in silico drug screening. Scientific Reports, 13(1), p.7577.